Assay Detail
Binding
CHEMBL658341
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Inhibitory activity against recombinant human cathepsin S (cat S) expressed in baculovirus
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.88 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336228 | — | — | 1 | 7.34 |
| CHEMBL342145 | — | — | 1 | 7.32 |
| CHEMBL140756 | — | — | 1 | 7.06 |
| CHEMBL140794 | — | — | 1 | 6.65 |
| CHEMBL134083 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336228 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL342145 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL140756 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL140794 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL134083 | — | IC50 | = | 937.0 | nM | 6.03 |