Assay Detail
Binding
CHEMBL658343
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Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirus
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.20 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153239 | — | — | 1 | 8.30 |
| CHEMBL155560 | — | — | 1 | 8.30 |
| CHEMBL356155 | — | — | 1 | 8.22 |
| CHEMBL347111 | — | — | 1 | 8.22 |
| CHEMBL356442 | — | — | 1 | 8.15 |
| CHEMBL153783 | — | — | 1 | 8.10 |
| CHEMBL150253 | — | — | 1 | 8.10 |
| CHEMBL435440 | — | — | 1 | 8.05 |
| CHEMBL356167 | — | — | 1 | 8.05 |
| CHEMBL153248 | — | — | 1 | 8.05 |
| CHEMBL149523 | — | — | 1 | 8.05 |
| CHEMBL152940 | — | — | 1 | 7.92 |
| CHEMBL150358 | — | — | 1 | 7.77 |
| CHEMBL346448 | — | — | 1 | 7.72 |
| CHEMBL153813 | — | — | 1 | 7.72 |
| CHEMBL153018 | — | — | 1 | 7.68 |
| CHEMBL348679 | — | — | 1 | 7.64 |
| CHEMBL151642 | — | — | 1 | 7.57 |
| CHEMBL150574 | — | — | 1 | 7.39 |
| CHEMBL153678 | — | — | 1 | 7.33 |
| CHEMBL347745 | — | — | 1 | 7.29 |
| CHEMBL153319 | — | — | 1 | 7.25 |
| CHEMBL435245 | — | — | 1 | 7.25 |
| CHEMBL153166 | — | — | 1 | 7.09 |
| CHEMBL345502 | — | — | 1 | 7.08 |
| CHEMBL345267 | — | — | 1 | 6.94 |
| CHEMBL153370 | — | — | 1 | 6.91 |
| CHEMBL154808 | — | — | 1 | 6.89 |
| CHEMBL149736 | — | — | 1 | 6.85 |
| CHEMBL356669 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153239 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL155560 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL347111 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL356155 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL356442 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL153783 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL150253 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL435440 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL356167 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL153248 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL149523 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL152940 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL150358 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL346448 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL153813 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL153018 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL348679 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL151642 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL150574 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL153678 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL347745 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL435245 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL153319 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL153166 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL345502 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL345267 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL153370 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL154808 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL149736 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL356669 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL358829 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL149687 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL357816 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL151641 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL358704 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL155102 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL434893 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL357117 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL358695 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL356588 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL347747 | — | IC50 | > | 339000.0 | nM | - |