Assay Detail
Binding
CHEMBL658345
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Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin S
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 8.82 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155560 | — | — | 1 | 10.00 |
| CHEMBL356442 | — | — | 1 | 10.00 |
| CHEMBL153813 | — | — | 1 | 9.52 |
| CHEMBL149523 | — | — | 1 | 9.52 |
| CHEMBL152940 | — | — | 1 | 9.52 |
| CHEMBL153018 | — | — | 1 | 9.40 |
| CHEMBL150253 | — | — | 1 | 9.40 |
| CHEMBL347111 | — | — | 1 | 9.40 |
| CHEMBL356167 | — | — | 1 | 9.30 |
| CHEMBL153783 | — | — | 1 | 9.22 |
| CHEMBL153248 | — | — | 1 | 9.22 |
| CHEMBL356155 | — | — | 1 | 9.15 |
| CHEMBL153239 | — | — | 1 | 9.10 |
| CHEMBL348679 | — | — | 1 | 9.05 |
| CHEMBL435440 | — | — | 1 | 9.00 |
| CHEMBL151642 | — | — | 1 | 8.70 |
| CHEMBL346448 | — | — | 1 | 8.52 |
| CHEMBL347745 | — | — | 1 | 8.40 |
| CHEMBL150358 | — | — | 1 | 8.40 |
| CHEMBL345502 | — | — | 1 | 8.30 |
| CHEMBL153319 | — | — | 1 | 8.15 |
| CHEMBL153678 | — | — | 1 | 8.15 |
| CHEMBL150574 | — | — | 1 | 8.05 |
| CHEMBL358829 | — | — | 1 | 7.55 |
| CHEMBL356669 | — | — | 1 | 7.22 |
| CHEMBL154808 | — | — | 1 | 7.20 |
| CHEMBL358695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155560 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL356442 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL153813 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL149523 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL152940 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL153018 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL150253 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL347111 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL356167 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL153783 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL153248 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL356155 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL153239 | — | Kd | = | 0.8 | nM | 9.10 |
| CHEMBL348679 | — | Kd | = | 0.9 | nM | 9.05 |
| CHEMBL435440 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL151642 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL346448 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL347745 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL150358 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL345502 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL153319 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL153678 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL150574 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL358829 | — | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL356669 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL154808 | — | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL358695 | — | Kd | > | 20000.0 | nM | - |