Assay Detail
Binding
CHEMBL658348
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Inhibition of human Cathepsin S
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyclic ketone inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.76 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118449 | — | — | 1 | 8.10 |
| CHEMBL423995 | — | — | 1 | 7.29 |
| CHEMBL100563 | — | — | 1 | 7.05 |
| CHEMBL2371402 | — | — | 1 | 6.54 |
| CHEMBL61805 | — | — | 1 | 6.51 |
| CHEMBL349445 | — | — | 1 | 6.32 |
| CHEMBL162631 | — | — | 1 | 6.28 |
| CHEMBL62239 | — | — | 1 | 5.96 |
| CHEMBL162389 | — | — | 1 | - |
| CHEMBL436437 | — | — | 1 | - |
| CHEMBL349823 | — | — | 1 | - |
| CHEMBL161964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118449 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL423995 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL100563 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL2371402 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL61805 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL349445 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL162631 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL62239 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL162389 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL436437 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL349823 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL161964 | — | Ki | > | 1000.0 | nM | - |