Assay Detail
Binding
CHEMBL658481
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Ability to block cathepsin B-catalyzed hydrolysis of the fluorogenic substrate Z-Arg-Arg-NHMec
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of peptidyl alpha-keto-beta-aldehydes as new inhibitors of cathepsin L--comparisons of potency and selectivity profiles with cathepsin B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.54 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51128 | — | — | 1 | 7.40 |
| CHEMBL48837 | — | — | 1 | 6.67 |
| CHEMBL48945 | — | — | 1 | 6.19 |
| CHEMBL48605 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51128 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL48837 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL48945 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL48605 | — | Ki | = | 1250.0 | nM | 5.90 |