Assay Detail
Functional
CHEMBL658489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral efficacy measured by a hybrid HIV-l/vaccinia virus infected monkey cell line (HIV- l/vVK-1 infected CV- 1) which produces HIV-1 gag-pol derived polyproteins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CV-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.17 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350189 | — | — | 1 | 6.70 |
| CHEMBL168093 | — | — | 1 | 6.52 |
| CHEMBL166175 | — | — | 1 | 6.52 |
| CHEMBL433729 | — | — | 1 | 6.52 |
| CHEMBL355867 | — | — | 1 | 6.52 |
| CHEMBL165706 | — | — | 1 | 6.52 |
| CHEMBL167514 | — | — | 1 | 6.52 |
| CHEMBL167442 | — | — | 1 | 6.52 |
| CHEMBL165480 | — | — | 1 | 6.30 |
| CHEMBL168651 | — | — | 1 | 5.52 |
| CHEMBL168779 | — | — | 1 | 5.52 |
| CHEMBL352967 | — | — | 1 | 5.52 |
| CHEMBL166640 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350189 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL168093 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL166175 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL433729 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL355867 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL165706 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL167514 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL167442 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL165480 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL168651 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL168779 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL352967 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL166640 | — | IC50 | = | 10000.0 | nM | 5.00 |