Assay Detail
Binding
CHEMBL658581
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Affinity for human Cathepsin K
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.75 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99890 | — | — | 2 | 8.85 |
| CHEMBL100563 | — | — | 1 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99890 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL100563 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL99890 | — | Ki | > | 1000.0 | nM | - |