Assay Detail
Binding
CHEMBL658623
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Inhibitory concentration required against human Caspase-3
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nicotinyl aspartyl ketones as inhibitors of caspase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.91 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417149 | — | — | 1 | 7.57 |
| CHEMBL308465 | — | — | 1 | 6.89 |
| CHEMBL68251 | — | — | 1 | 6.89 |
| CHEMBL303864 | — | — | 1 | 6.77 |
| CHEMBL66937 | — | — | 1 | 6.77 |
| CHEMBL432331 | — | — | 1 | 6.60 |
| CHEMBL303405 | — | — | 1 | 6.57 |
| CHEMBL65959 | — | — | 1 | 6.52 |
| CHEMBL420366 | — | — | 1 | 6.47 |
| CHEMBL302972 | — | — | 1 | 6.41 |
| CHEMBL66048 | — | — | 1 | 6.40 |
| CHEMBL66690 | — | — | 1 | 6.39 |
| CHEMBL68379 | — | — | 1 | 6.28 |
| CHEMBL65994 | — | — | 1 | 6.21 |
| CHEMBL421678 | — | — | 1 | 5.97 |
| CHEMBL422409 | — | — | 1 | 5.96 |
| CHEMBL306452 | — | — | 1 | 5.92 |
| CHEMBL67955 | — | — | 1 | 5.22 |
| CHEMBL67398 | — | — | 1 | 5.00 |
| CHEMBL70071 | — | — | 1 | 4.93 |
| CHEMBL306915 | — | — | 1 | 4.86 |
| CHEMBL67186 | — | — | 1 | 4.64 |
| CHEMBL304276 | — | — | 1 | 4.26 |
| CHEMBL67349 | — | — | 1 | 4.20 |
| CHEMBL69426 | — | — | 1 | 4.01 |
| CHEMBL67956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417149 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL308465 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL68251 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL303864 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL66937 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL432331 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL303405 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL65959 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL420366 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL302972 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL66048 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL66690 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL68379 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL65994 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL421678 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL422409 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL306452 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL67955 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL67398 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL70071 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL306915 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL67186 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL304276 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL67349 | — | IC50 | = | 63700.0 | nM | 4.20 |
| CHEMBL69426 | — | IC50 | = | 96900.0 | nM | 4.01 |
| CHEMBL67956 | — | IC50 | > | 200000.0 | nM | - |