Assay Detail
Binding
CHEMBL658748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against bCA -IV
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 64 | 7.28 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123167 | — | — | 1 | 8.00 |
| CHEMBL331669 | — | — | 1 | 8.00 |
| CHEMBL331114 | — | — | 1 | 7.92 |
| CHEMBL333532 | — | — | 1 | 7.92 |
| CHEMBL122925 | — | — | 1 | 7.89 |
| CHEMBL121501 | — | — | 1 | 7.89 |
| CHEMBL332406 | — | — | 1 | 7.89 |
| CHEMBL332858 | — | — | 1 | 7.80 |
| CHEMBL332362 | — | — | 1 | 7.80 |
| CHEMBL331308 | — | — | 1 | 7.80 |
| CHEMBL332429 | — | — | 1 | 7.77 |
| CHEMBL120049 | — | — | 1 | 7.72 |
| CHEMBL333248 | — | — | 1 | 7.70 |
| CHEMBL122109 | — | — | 1 | 7.68 |
| CHEMBL121592 | — | — | 1 | 7.62 |
| CHEMBL332439 | — | — | 1 | 7.57 |
| CHEMBL83508 | — | — | 1 | 7.54 |
| CHEMBL333896 | — | — | 1 | 7.52 |
| CHEMBL123443 | — | — | 1 | 7.52 |
| CHEMBL121916 | — | — | 1 | 7.42 |
| CHEMBL123382 | — | — | 1 | 7.41 |
| CHEMBL123404 | — | — | 1 | 7.41 |
| CHEMBL123233 | — | — | 1 | 7.40 |
| CHEMBL262676 | — | — | 1 | 7.38 |
| CHEMBL123463 | — | — | 1 | 7.37 |
| CHEMBL120934 | — | — | 1 | 7.35 |
| CHEMBL332755 | — | — | 1 | 7.32 |
| CHEMBL122711 | — | — | 1 | 7.31 |
| CHEMBL123105 | — | — | 1 | 7.26 |
| CHEMBL98328 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123167 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL331669 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL333532 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL331114 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL122925 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL121501 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL332406 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL332858 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL332362 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL331308 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL332429 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL120049 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL333248 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL122109 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL121592 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL332439 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL83508 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL333896 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL123443 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL121916 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL123382 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL123404 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL123233 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL262676 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL123463 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL120934 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL332755 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL122711 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL123105 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL98328 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL121729 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL55310 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL340461 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL332145 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL441084 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL123041 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL122868 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL301469 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL122719 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL330857 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL121559 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL293503 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL55110 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL122950 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL316169 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL331311 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL122651 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL82868 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL123064 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL311336 | — | Ki | = | 185.0 | nM | 6.73 |