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Assay Detail

CHEMBL658749

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Binding
Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes
ChEMBL ↗
130
Total Activities
130
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 4 (CHEMBL281) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Scozzafava A, Briganti F, Ilies MA, Supuran CT.
J Med Chem (2000) 43 : 292 -300
PubMed 10649985 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 130 7.16 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL13630 — — 1 9.10
CHEMBL268439 — — 1 8.30
CHEMBL103630 — — 1 8.10
CHEMBL319487 — — 1 8.05
CHEMBL102722 — — 1 8.05
CHEMBL100860 — — 1 8.00
CHEMBL97795 — — 1 8.00
CHEMBL101330 — — 1 8.00
CHEMBL317256 — — 1 8.00
CHEMBL101190 — — 1 7.92
CHEMBL287117 — — 1 7.82
CHEMBL99855 — — 1 7.82
CHEMBL100906 — — 1 7.80
CHEMBL100733 — — 1 7.80
CHEMBL318953 — — 1 7.80
CHEMBL103392 — — 1 7.77
CHEMBL6685 — — 1 7.77
CHEMBL103770 — — 1 7.77
CHEMBL99736 — — 1 7.75
CHEMBL35118 — — 1 7.72
CHEMBL103015 — — 1 7.72
CHEMBL421200 — — 1 7.72
CHEMBL103420 — — 1 7.60
CHEMBL439957 — — 1 7.60
CHEMBL319297 — — 1 7.60
CHEMBL100456 — — 1 7.57
CHEMBL431421 — — 1 7.54
CHEMBL103615 — — 1 7.52
CHEMBL319182 — — 1 7.52
CHEMBL100075 — — 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL13630 — Ki = 0.8 nM 9.10
CHEMBL268439 — Ki = 5.0 nM 8.30
CHEMBL103630 — Ki = 8.0 nM 8.10
CHEMBL319487 — Ki = 9.0 nM 8.05
CHEMBL102722 — Ki = 9.0 nM 8.05
CHEMBL100860 — Ki = 10.0 nM 8.00
CHEMBL97795 — Ki = 10.0 nM 8.00
CHEMBL317256 — Ki = 10.0 nM 8.00
CHEMBL101330 — Ki = 10.0 nM 8.00
CHEMBL101190 — Ki = 12.0 nM 7.92
CHEMBL287117 — Ki = 15.0 nM 7.82
CHEMBL99855 — Ki = 15.0 nM 7.82
CHEMBL100906 — Ki = 16.0 nM 7.80
CHEMBL318953 — Ki = 16.0 nM 7.80
CHEMBL100733 — Ki = 16.0 nM 7.80
CHEMBL103392 — Ki = 17.0 nM 7.77
CHEMBL6685 — Ki = 17.0 nM 7.77
CHEMBL103770 — Ki = 17.0 nM 7.77
CHEMBL99736 — Ki = 18.0 nM 7.75
CHEMBL103015 — Ki = 19.0 nM 7.72
CHEMBL421200 — Ki = 19.0 nM 7.72
CHEMBL35118 — Ki = 19.0 nM 7.72
CHEMBL103420 — Ki = 25.0 nM 7.60
CHEMBL439957 — Ki = 25.0 nM 7.60
CHEMBL319297 — Ki = 25.0 nM 7.60
CHEMBL100456 — Ki = 27.0 nM 7.57
CHEMBL431421 — Ki = 29.0 nM 7.54
CHEMBL319182 — Ki = 30.0 nM 7.52
CHEMBL103615 — Ki = 30.0 nM 7.52
CHEMBL100075 — Ki = 30.0 nM 7.52
CHEMBL103413 — Ki = 31.0 nM 7.51
CHEMBL318839 — Ki = 33.0 nM 7.48
CHEMBL103524 — Ki = 33.0 nM 7.48
CHEMBL103415 — Ki = 33.0 nM 7.48
CHEMBL103398 — Ki = 35.0 nM 7.46
CHEMBL319897 — Ki = 35.0 nM 7.46
CHEMBL318486 — Ki = 35.0 nM 7.46
CHEMBL321795 — Ki = 36.0 nM 7.44
CHEMBL102904 — Ki = 36.0 nM 7.44
CHEMBL102401 — Ki = 36.0 nM 7.44
CHEMBL318969 — Ki = 38.0 nM 7.42
CHEMBL420105 — Ki = 38.0 nM 7.42
CHEMBL103478 — Ki = 39.0 nM 7.41
CHEMBL100760 — Ki = 39.0 nM 7.41
CHEMBL102068 — Ki = 39.0 nM 7.41
CHEMBL316957 — Ki = 42.0 nM 7.38
CHEMBL554264 — Ki = 44.0 nM 7.36
CHEMBL99697 — Ki = 46.0 nM 7.34
CHEMBL317249 — Ki = 46.0 nM 7.34
CHEMBL328410 — Ki = 46.0 nM 7.34