Assay Detail
Binding
CHEMBL658750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.70 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268439 | — | — | 1 | 8.30 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.89 |
| CHEMBL6685 | — | — | 1 | 7.77 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.44 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.35 |
| CHEMBL6724 | — | — | 1 | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.16 |
| CHEMBL266026 | — | — | 1 | 7.14 |
| CHEMBL7146 | — | — | 1 | 7.14 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.07 |
| CHEMBL268177 | — | — | 1 | 6.90 |
| CHEMBL269122 | — | — | 1 | 6.89 |
| CHEMBL6946 | — | — | 1 | 6.84 |
| CHEMBL6633 | — | — | 1 | 6.81 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.81 |
| CHEMBL266240 | — | — | 1 | 6.80 |
| CHEMBL6853 | — | — | 1 | 6.75 |
| CHEMBL7092 | — | — | 1 | 6.50 |
| CHEMBL6753 | — | — | 1 | 6.45 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.42 |
| CHEMBL268809 | — | — | 1 | 6.38 |
| CHEMBL6648 | — | — | 1 | 6.36 |
| CHEMBL6784 | — | — | 1 | 6.35 |
| CHEMBL265674 | — | — | 1 | 6.27 |
| CHEMBL6919 | — | — | 1 | 6.25 |
| CHEMBL6705 | — | — | 1 | 5.88 |
| CHEMBL6852 | — | — | 1 | 5.66 |
| CHEMBL7087 | — | — | 1 | 5.61 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268439 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL6685 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL6724 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL266026 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL7146 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL414 | CARZENIDE | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL268177 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL269122 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL6946 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL6633 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL266240 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL6853 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL7092 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL6753 | — | Ki | = | 355.0 | nM | 6.45 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL268809 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL6648 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL6784 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL265674 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL6919 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL6705 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL6852 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL7087 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL419 | MAFENIDE | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL7204 | — | Ki | = | 3215.0 | nM | 5.49 |