Assay Detail
Binding
CHEMBL658780
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Half-maximal inhibition of [125I]CCK-33 binding to guinea pig brain(cortex) cholecystokinin receptor
65
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 4.40 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907731 | — | — | 1 | 5.00 |
| CHEMBL1907717 | — | — | 1 | 5.00 |
| CHEMBL1907719 | — | — | 1 | 4.96 |
| CHEMBL1907735 | — | — | 1 | 4.80 |
| CHEMBL1907729 | — | — | 1 | 4.77 |
| CHEMBL1907728 | — | — | 1 | 4.64 |
| CHEMBL2092989 | — | — | 1 | 4.55 |
| CHEMBL1907720 | — | — | 1 | 4.52 |
| CHEMBL1907737 | — | — | 1 | 4.52 |
| CHEMBL1907742 | — | — | 1 | 4.52 |
| CHEMBL20223 | — | — | 1 | 4.48 |
| CHEMBL279237 | — | — | 1 | 4.47 |
| CHEMBL1907930 | — | — | 1 | 4.44 |
| CHEMBL51569 | — | — | 1 | 4.41 |
| CHEMBL2092991 | — | — | 1 | 4.32 |
| CHEMBL429063 | — | — | 1 | 4.32 |
| CHEMBL552817 | — | — | 1 | 4.30 |
| CHEMBL1907740 | — | — | 1 | 4.30 |
| CHEMBL2092748 | — | — | 1 | 4.27 |
| CHEMBL1907736 | — | — | 1 | 4.22 |
| CHEMBL20514 | — | — | 1 | 4.21 |
| CHEMBL1907724 | — | — | 1 | 4.20 |
| CHEMBL1907725 | — | — | 1 | 4.18 |
| CHEMBL1907734 | — | — | 1 | 4.10 |
| CHEMBL1907714 | — | — | 1 | 4.10 |
| CHEMBL2092990 | — | — | 1 | 4.03 |
| CHEMBL1907712 | — | — | 1 | 4.00 |
| CHEMBL429391 | — | — | 1 | 4.00 |
| CHEMBL1907723 | — | — | 1 | 4.00 |
| CHEMBL20872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907731 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1907717 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1907719 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1907735 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1907729 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1907728 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2092989 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1907737 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1907742 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1907720 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL20223 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL279237 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1907930 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL51569 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL429063 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL2092991 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL552817 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1907740 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2092748 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1907736 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL20514 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1907724 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1907725 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL1907714 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1907734 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2092990 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL1907712 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL429391 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1907723 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1907929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092746 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL452 | CLONAZEPAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL430336 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL21770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907932 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2092988 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907727 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283117 | ASPERLICIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20872 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL70728 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907743 | — | IC50 | ~ | 30000.0 | nM | - |
| CHEMBL1907721 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907730 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL283946 | — | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL1907718 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907738 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1907716 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3350230 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20683 | — | IC50 | > | 100000.0 | nM | - |