Assay Detail
Binding
CHEMBL658897
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Binding affinity against Cannabinoid receptor 1 in rat forebrain
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.22 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285932 | — | — | 1 | 8.13 |
| CHEMBL36569 | — | — | 1 | 8.11 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 7.94 |
| CHEMBL34201 | — | — | 1 | 7.93 |
| CHEMBL286188 | — | — | 1 | 7.78 |
| CHEMBL167661 | — | — | 1 | 7.77 |
| CHEMBL35657 | — | — | 1 | 7.51 |
| CHEMBL33652 | — | — | 1 | 7.27 |
| CHEMBL165134 | — | — | 1 | 7.27 |
| CHEMBL349512 | — | — | 1 | 7.24 |
| CHEMBL36250 | — | — | 1 | 7.22 |
| CHEMBL285473 | — | — | 1 | 7.12 |
| CHEMBL349955 | — | — | 1 | 7.09 |
| CHEMBL285153 | — | — | 1 | 6.91 |
| CHEMBL352460 | — | — | 1 | 6.90 |
| CHEMBL354476 | — | — | 1 | 6.74 |
| CHEMBL349513 | — | — | 1 | 6.59 |
| CHEMBL422034 | — | — | 1 | 6.49 |
| CHEMBL424527 | — | — | 1 | 6.46 |
| CHEMBL285486 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285932 | — | Ki | = | 7.49 | nM | 8.13 |
| CHEMBL36569 | — | Ki | = | 7.85 | nM | 8.11 |
| CHEMBL111 | RIMONABANT | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL34201 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL286188 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL167661 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL35657 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL33652 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL165134 | — | Ki | = | 53.8 | nM | 7.27 |
| CHEMBL349512 | — | Ki | = | 57.5 | nM | 7.24 |
| CHEMBL36250 | — | Ki | = | 60.4 | nM | 7.22 |
| CHEMBL285473 | — | Ki | = | 76.7 | nM | 7.12 |
| CHEMBL349955 | — | Ki | = | 81.5 | nM | 7.09 |
| CHEMBL285153 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL352460 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL354476 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL349513 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL422034 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL424527 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL285486 | — | Ki | = | 1120.0 | nM | 5.95 |