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Compound Detail

CHEMBL36250

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Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2)c1-c1ccc(Cl)cc1

Basic Information

ChEMBL ID CHEMBL36250
Phase Preclinical
Structure Type MOL
InChI Key JDFAIQMMRYUITC-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

429.4
MW (Da)
5.29
ALogP
4
HBA
1
HBD
50.2
PSA (Ų)
0.61
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H22Cl2N4O
MW 429.35
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -1.28

Activity Summary

Ki 5 meas. best 7.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL3571
Ki 7.26 7.24 55.0 2
Cannabinoid receptor 1
CHEMBL218
Ki 7.22 7.22 60.4 2
Cannabinoid receptor 2
CHEMBL5373
Ki 6.08 6.08 836.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-012-0418-y Cannabinoid receptor 1 2
10052983 10.1021/jm980363y Cannabinoid receptor 1 1
10052983 10.1021/jm980363y Cannabinoid receptor 2 1
10052983 10.1021/jm980363y Cannabinoid receptor 1
11906286 10.1021/jm010267o Cannabinoid receptor 1 1

Data from ChEMBL 36 via Core Engine