Assay Detail
Binding
CHEMBL659698
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Inhibition of [3H]CP-55940 binding to cannabinoid receptor 1 in rat brain membranes.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.38 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287610 | — | — | 1 | 9.00 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.89 |
| CHEMBL432272 | — | — | 1 | 8.52 |
| CHEMBL284710 | — | — | 1 | 8.52 |
| CHEMBL287017 | — | — | 1 | 8.22 |
| CHEMBL285932 | — | — | 1 | 8.22 |
| CHEMBL287353 | — | — | 1 | 8.15 |
| CHEMBL36569 | — | — | 1 | 8.11 |
| CHEMBL34201 | — | — | 1 | 7.82 |
| CHEMBL286188 | — | — | 1 | 7.78 |
| CHEMBL286302 | — | — | 1 | 7.77 |
| CHEMBL33652 | — | — | 1 | 7.72 |
| CHEMBL36032 | — | — | 1 | 7.68 |
| CHEMBL286222 | — | — | 1 | 7.64 |
| CHEMBL287609 | — | — | 1 | 7.60 |
| CHEMBL35657 | — | — | 1 | 7.51 |
| CHEMBL32855 | — | — | 1 | 7.43 |
| CHEMBL287472 | — | — | 1 | 7.33 |
| CHEMBL36250 | — | — | 1 | 7.26 |
| CHEMBL285473 | — | — | 1 | 7.25 |
| CHEMBL285259 | — | — | 1 | 7.20 |
| CHEMBL285964 | — | — | 1 | 7.14 |
| CHEMBL35835 | — | — | 1 | 7.00 |
| CHEMBL34805 | — | — | 1 | 6.96 |
| CHEMBL285153 | — | — | 1 | 6.91 |
| CHEMBL285486 | — | — | 1 | 6.78 |
| CHEMBL35918 | — | — | 1 | 6.74 |
| CHEMBL284331 | — | — | 1 | 6.73 |
| CHEMBL36232 | — | — | 1 | 6.70 |
| CHEMBL2113343 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287610 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL111 | RIMONABANT | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL432272 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL284710 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL287017 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL285932 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL287353 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL36569 | — | Ki | = | 7.85 | nM | 8.11 |
| CHEMBL34201 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL286188 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL286302 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL33652 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL36032 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL286222 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL287609 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL35657 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL32855 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL287472 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL36250 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL285473 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL285259 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL285964 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL35835 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL34805 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL285153 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL285486 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL35918 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL284331 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL36232 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL2113343 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL285026 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL432857 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL36579 | — | Ki | = | 746.0 | nM | 6.13 |
| CHEMBL32929 | — | Ki | = | 771.0 | nM | 6.11 |
| CHEMBL36553 | — | Ki | = | 1360.0 | nM | 5.87 |