Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3070221

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at CB1 receptor (unknown origin)
ChEMBL ↗
52
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL218) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Activity landscape analysis, CoMFA and CoMSIA studies of pyrazole CB1 antagonists
Hernandez-Vazquez E, Mendez-Lucio O, Hernandez-Luis F
Med Chem Res (2013) 22 : 4133 -4145
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 52 6.98 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2296777 — — 2 8.22
CHEMBL2296781 — — 2 8.22
CHEMBL285932 — — 2 8.13
CHEMBL2296784 — — 2 7.93
CHEMBL476833 — — 2 7.88
CHEMBL2296786 — — 2 7.74
CHEMBL2296782 — — 2 7.70
CHEMBL2296783 — — 2 7.51
CHEMBL2296779 — — 2 7.33
CHEMBL36250 — — 2 7.22
CHEMBL2296780 — — 2 7.20
CHEMBL286188 — — 2 7.12
CHEMBL349955 — — 2 7.09
CHEMBL285259 — — 2 7.09
CHEMBL2296774 — — 2 7.00
CHEMBL285153 — — 2 6.91
CHEMBL287472 — — 2 6.69
CHEMBL2296785 — — 2 6.62
CHEMBL2296775 — — 2 6.59
CHEMBL2296776 — — 2 6.49
CHEMBL94239 — — 2 6.43
CHEMBL2296787 — — 2 6.40
CHEMBL432857 — — 2 6.22
CHEMBL285486 — — 2 5.95
CHEMBL32929 — — 2 5.45
CHEMBL2296778 — — 2 4.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2296781 — Ki = 6.0 nM 8.22
CHEMBL2296777 — Ki = 6.0 nM 8.22
CHEMBL2296777 — Ki = 5.984 nM 8.22
CHEMBL2296781 — Ki = 5.998 nM 8.22
CHEMBL285932 — Ki = 7.482 nM 8.13
CHEMBL285932 — Ki = 7.5 nM 8.12
CHEMBL2296784 — Ki = 11.67 nM 7.93
CHEMBL2296784 — Ki = 11.7 nM 7.93
CHEMBL476833 — Ki = 13.24 nM 7.88
CHEMBL476833 — Ki = 13.2 nM 7.88
CHEMBL2296786 — Ki = 18.2 nM 7.74
CHEMBL2296786 — Ki = 18.2 nM 7.74
CHEMBL2296782 — Ki = 19.82 nM 7.70
CHEMBL2296782 — Ki = 19.8 nM 7.70
CHEMBL2296783 — Ki = 31.1 nM 7.51
CHEMBL2296783 — Ki = 31.12 nM 7.51
CHEMBL2296779 — Ki = 47.0 nM 7.33
CHEMBL2296779 — Ki = 46.99 nM 7.33
CHEMBL36250 — Ki = 60.39 nM 7.22
CHEMBL36250 — Ki = 60.4 nM 7.22
CHEMBL2296780 — Ki = 62.95 nM 7.20
CHEMBL2296780 — Ki = 63.0 nM 7.20
CHEMBL286188 — Ki = 76.7 nM 7.12
CHEMBL286188 — Ki = 76.74 nM 7.12
CHEMBL349955 — Ki = 81.5 nM 7.09
CHEMBL349955 — Ki = 81.47 nM 7.09
CHEMBL285259 — Ki = 81.85 nM 7.09
CHEMBL285259 — Ki = 81.8 nM 7.09
CHEMBL2296774 — Ki = 100.0 nM 7.00
CHEMBL2296774 — Ki = 100.0 nM 7.00
CHEMBL285153 — Ki = 122.74 nM 6.91
CHEMBL285153 — Ki = 122.7 nM 6.91
CHEMBL287472 — Ki = 203.24 nM 6.69
CHEMBL287472 — Ki = 203.2 nM 6.69
CHEMBL2296785 — Ki = 240.99 nM 6.62
CHEMBL2296785 — Ki = 241.0 nM 6.62
CHEMBL2296775 — Ki = 256.4 nM 6.59
CHEMBL2296775 — Ki = 256.45 nM 6.59
CHEMBL2296776 — Ki = 327.3 nM 6.49
CHEMBL2296776 — Ki = 327.34 nM 6.49
CHEMBL94239 — Ki = 374.1 nM 6.43
CHEMBL94239 — Ki = 374.11 nM 6.43
CHEMBL2296787 — Ki = 399.9 nM 6.40
CHEMBL2296787 — Ki = 399.94 nM 6.40
CHEMBL432857 — Ki = 605.3 nM 6.22
CHEMBL432857 — Ki = 605.34 nM 6.22
CHEMBL285486 — Ki = 1119.4 nM 5.95
CHEMBL285486 — Ki = 1119.44 nM 5.95
CHEMBL32929 — Ki = 3564.5 nM 5.45
CHEMBL32929 — Ki = 3564.51 nM 5.45