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Compound Detail

CHEMBL2296785

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COCc1c(C(=O)NC2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1C1C2(C)CCC(C2)C1(C)C

Basic Information

ChEMBL ID CHEMBL2296785
Phase Preclinical
Structure Type MOL
InChI Key BYNMFBSZECDGSU-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

518.5
MW (Da)
7.32
ALogP
4
HBA
1
HBD
56.1
PSA (Ų)
0.44
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H37Cl2N3O2
MW 518.53
Aromatic Rings 2
Heavy Atoms 35
NP-Likeness -0.41

Activity Summary

Ki 2 meas. best 6.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL218
Ki 6.62 6.62 241.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-012-0418-y Cannabinoid receptor 1 2

Data from ChEMBL 36 via Core Engine