Assay Detail
Binding
CHEMBL658956
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Binding affinity to Cannabinoid receptor 2 using African green monkey (COS-7) cells Chinese hamster ovary(CHO) cells transfected with the cDNA of human CB2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.35 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432107 | — | — | 1 | 9.77 |
| CHEMBL111724 | — | — | 1 | 9.70 |
| CHEMBL111148 | — | — | 1 | 9.70 |
| CHEMBL109393 | — | — | 1 | 8.82 |
| CHEMBL111340 | — | — | 1 | 8.32 |
| CHEMBL111099 | — | — | 1 | 8.13 |
| CHEMBL111702 | — | — | 1 | 7.76 |
| CHEMBL113230 | — | — | 1 | 7.76 |
| CHEMBL109972 | — | — | 1 | 7.58 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.49 |
| CHEMBL320408 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432107 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL111724 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL111148 | — | Ki | = | 0.199 | nM | 9.70 |
| CHEMBL109393 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL111340 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL111099 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL111702 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL113230 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL109972 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL465 | DRONABINOL | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL320408 | — | Ki | = | 170.5 | nM | 6.77 |