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Assay Detail

CHEMBL658990

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of HCO3- stimulated swelling in cat cerebrocortical tissue slice
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Felis catus
Confidence 1 — Organism
Curated By Expert

Target

Felis catus (CHEMBL612670)
Type ORGANISM
Organism Felis catus

Publication

Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids.
Cragoe EJ, Gould NP, Woltersdorf OW, Ziegler C, Bourke RS, Nelson LR, Kimelberg HK, Waldman JB, Popp AJ, Sedransk N.
J Med Chem (1982) 25 : 567 -579
PubMed 7086844 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.98 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1397882 1 9.52
CHEMBL154681 1 9.00
CHEMBL152717 1 9.00
CHEMBL346777 1 8.52
CHEMBL152557 1 8.40
CHEMBL2114181 1 8.00
CHEMBL435082 1 8.00
CHEMBL82598 1 7.70
CHEMBL1256718 1 7.00
CHEMBL79956 1 6.70
CHEMBL3350288 1 6.60
CHEMBL3350262 1 6.60
CHEMBL84189 1 6.30
CHEMBL7797 INDACRINONE 2.0 1 6.00
CHEMBL2111216 1 6.00
CHEMBL154324 1 6.00
CHEMBL456 ETHACRYNIC ACID 4.0 1 6.00
CHEMBL35 FUROSEMIDE 4.0 1 5.00
CHEMBL404814 1 5.00
CHEMBL1256719 1 4.30
CHEMBL358617 1 -
CHEMBL154542 1 -
CHEMBL20 ACETAZOLAMIDE 4.0 1 -
CHEMBL154049 1 -
CHEMBL152193 1 -
CHEMBL152119 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1397882 IC50 = 0.3 nM 9.52
CHEMBL154681 IC50 = 1.0 nM 9.00
CHEMBL152717 IC50 = 1.0 nM 9.00
CHEMBL346777 IC50 = 3.0 nM 8.52
CHEMBL152557 IC50 = 4.0 nM 8.40
CHEMBL2114181 IC50 = 10.0 nM 8.00
CHEMBL435082 IC50 = 10.0 nM 8.00
CHEMBL82598 IC50 = 20.0 nM 7.70
CHEMBL1256718 IC50 = 100.0 nM 7.00
CHEMBL79956 IC50 = 200.0 nM 6.70
CHEMBL3350288 IC50 = 250.0 nM 6.60
CHEMBL3350262 IC50 = 250.0 nM 6.60
CHEMBL84189 IC50 = 500.0 nM 6.30
CHEMBL7797 INDACRINONE IC50 = 1000.0 nM 6.00
CHEMBL2111216 IC50 = 1000.0 nM 6.00
CHEMBL154324 IC50 = 1000.0 nM 6.00
CHEMBL456 ETHACRYNIC ACID IC50 = 1000.0 nM 6.00
CHEMBL35 FUROSEMIDE IC50 = 10000.0 nM 5.00
CHEMBL404814 IC50 = 10000.0 nM 5.00
CHEMBL1256719 IC50 = 50000.0 nM 4.30
CHEMBL358617 IC50 > 10.0 nM -
CHEMBL154542 IC50 > 10000.0 nM -
CHEMBL20 ACETAZOLAMIDE IC50 = 2000000.0 nM -
CHEMBL154049 IC50 > 100000.0 nM -
CHEMBL152193 IC50 > 40000.0 nM -
CHEMBL152119 IC50 > 100000.0 nM -