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Assay Detail

CHEMBL659000

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Binding
Inhibition of bovine cathepsin B
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Cathepsin B (CHEMBL2323) ↗
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases.
Li Z, Ortega-Vilain AC, Patil GS, Chu DL, Foreman JE, Eveleth DD, Powers JC.
J Med Chem (1996) 39 : 4089 -4098
PubMed 8831774 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 45 6.50 7.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL131540 — — 1 7.51
CHEMBL132987 — — 1 7.20
CHEMBL421910 — — 1 7.20
CHEMBL130122 — — 1 7.14
CHEMBL3706739 — — 1 7.03
CHEMBL131707 — — 1 7.02
CHEMBL131639 — — 1 7.00
CHEMBL130345 — — 1 6.96
CHEMBL133521 — — 1 6.96
CHEMBL130629 — — 1 6.96
CHEMBL130599 — — 1 6.92
CHEMBL413308 — — 1 6.92
CHEMBL341219 — — 1 6.92
CHEMBL435203 — — 1 6.85
CHEMBL3706740 — — 1 6.85
CHEMBL129831 — — 1 6.82
CHEMBL132526 — — 1 6.77
CHEMBL334744 — — 1 6.72
CHEMBL131002 — — 1 6.68
CHEMBL339174 — — 1 6.68
CHEMBL335706 — — 1 6.66
CHEMBL130580 — — 1 6.66
CHEMBL130359 — — 1 6.66
CHEMBL132566 — — 1 6.64
CHEMBL339869 — — 1 6.62
CHEMBL134092 — — 1 6.52
CHEMBL132732 — — 1 6.51
CHEMBL130146 — — 1 6.50
CHEMBL131866 — — 1 6.48
CHEMBL337462 — — 1 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL131540 — Ki = 31.0 nM 7.51
CHEMBL132987 — Ki = 63.0 nM 7.20
CHEMBL421910 — Ki = 63.0 nM 7.20
CHEMBL130122 — Ki = 72.0 nM 7.14
CHEMBL3706739 — Ki = 94.0 nM 7.03
CHEMBL131707 — Ki = 96.0 nM 7.02
CHEMBL131639 — Ki = 100.0 nM 7.00
CHEMBL130345 — Ki = 110.0 nM 6.96
CHEMBL133521 — Ki = 110.0 nM 6.96
CHEMBL130629 — Ki = 110.0 nM 6.96
CHEMBL413308 — Ki = 120.0 nM 6.92
CHEMBL341219 — Ki = 120.0 nM 6.92
CHEMBL130599 — Ki = 120.0 nM 6.92
CHEMBL435203 — Ki = 140.0 nM 6.85
CHEMBL3706740 — Ki = 140.0 nM 6.85
CHEMBL129831 — Ki = 150.0 nM 6.82
CHEMBL132526 — Ki = 170.0 nM 6.77
CHEMBL334744 — Ki = 190.0 nM 6.72
CHEMBL131002 — Ki = 210.0 nM 6.68
CHEMBL339174 — Ki = 210.0 nM 6.68
CHEMBL130359 — Ki = 220.0 nM 6.66
CHEMBL335706 — Ki = 220.0 nM 6.66
CHEMBL130580 — Ki = 220.0 nM 6.66
CHEMBL132566 — Ki = 230.0 nM 6.64
CHEMBL339869 — Ki = 240.0 nM 6.62
CHEMBL134092 — Ki = 300.0 nM 6.52
CHEMBL132732 — Ki = 310.0 nM 6.51
CHEMBL130146 — Ki = 320.0 nM 6.50
CHEMBL131866 — Ki = 330.0 nM 6.48
CHEMBL337462 — Ki = 350.0 nM 6.46
CHEMBL337830 — Ki = 380.0 nM 6.42
CHEMBL133970 — Ki = 450.0 nM 6.35
CHEMBL131779 — Ki = 550.0 nM 6.26
CHEMBL133749 — Ki = 570.0 nM 6.24
CHEMBL133707 — Ki = 640.0 nM 6.19
CHEMBL337684 — Ki = 640.0 nM 6.19
CHEMBL273817 — Ki = 660.0 nM 6.18
CHEMBL130722 — Ki = 880.0 nM 6.06
CHEMBL131257 — Ki = 1200.0 nM 5.92
CHEMBL337608 — Ki = 1700.0 nM 5.77
CHEMBL133936 — Ki = 2100.0 nM 5.68
CHEMBL133243 — Ki = 3400.0 nM 5.47
CHEMBL338957 — Ki = 4300.0 nM 5.37
CHEMBL116863 — Ki = 8000.0 nM 5.10
CHEMBL133806 — Ki = 20000.0 nM 4.70