Assay Detail
Binding
CHEMBL659048
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Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 7.59 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69229 | — | — | 1 | 8.77 |
| CHEMBL302706 | — | — | 1 | 8.72 |
| CHEMBL304757 | — | — | 1 | 8.72 |
| CHEMBL71611 | — | — | 1 | 8.70 |
| CHEMBL305488 | — | — | 1 | 8.70 |
| CHEMBL308677 | — | — | 1 | 8.68 |
| CHEMBL68506 | — | — | 1 | 8.64 |
| CHEMBL71657 | — | — | 1 | 8.64 |
| CHEMBL307698 | — | — | 1 | 8.62 |
| CHEMBL70524 | — | — | 1 | 8.62 |
| CHEMBL304973 | — | — | 1 | 8.60 |
| CHEMBL68639 | — | — | 1 | 8.60 |
| CHEMBL306832 | — | — | 1 | 8.57 |
| CHEMBL278603 | — | — | 1 | 8.40 |
| CHEMBL23435 | — | — | 1 | 8.38 |
| CHEMBL303905 | — | — | 1 | 8.35 |
| CHEMBL22540 | — | — | 1 | 8.34 |
| CHEMBL268439 | — | — | 1 | 8.30 |
| CHEMBL282021 | — | — | 1 | 8.09 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.44 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.35 |
| CHEMBL69347 | — | — | 1 | 7.24 |
| CHEMBL6724 | — | — | 1 | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.16 |
| CHEMBL70873 | — | — | 1 | 7.02 |
| CHEMBL304322 | — | — | 1 | 6.98 |
| CHEMBL303648 | — | — | 1 | 6.95 |
| CHEMBL441054 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69229 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL302706 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL304757 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL71611 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL305488 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL308677 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL68506 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL71657 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL307698 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL70524 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL304973 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL68639 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL306832 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL278603 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL23435 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL303905 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL22540 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL268439 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL282021 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL69347 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL6724 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL70873 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL304322 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL303648 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL441054 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL69813 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL268177 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL70020 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL306195 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL6853 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL68605 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL430810 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL308459 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL430600 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL67755 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL7092 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL265674 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 3000.0 | nM | 5.52 |