Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL659084

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell
ChEMBL ↗
141
Total Activities
141
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

C-C chemokine receptor type 5 (CHEMBL274) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Shu M, Loebach JL, Parker KA, Mills SG, Chapman KT, Shen DM, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Salvo JD, Lyons K, Pivnichny JV, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.
Bioorg Med Chem Lett (2004) 14 : 947 -952
PubMed 15012999 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 141 9.08 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL369235 — — 1 9.70
CHEMBL366770 — — 1 9.70
CHEMBL173400 — — 1 9.70
CHEMBL174927 — — 1 9.70
CHEMBL171958 — — 1 9.70
CHEMBL427493 — — 1 9.52
CHEMBL368329 — — 1 9.52
CHEMBL174004 — — 1 9.52
CHEMBL279992 — — 1 9.52
CHEMBL172916 — — 1 9.52
CHEMBL177127 — — 1 9.52
CHEMBL435472 — — 1 9.52
CHEMBL172894 — — 1 9.52
CHEMBL367987 — — 1 9.52
CHEMBL366868 — — 1 9.52
CHEMBL369059 — — 1 9.52
CHEMBL369812 — — 1 9.40
CHEMBL366873 — — 1 9.40
CHEMBL176669 — — 1 9.40
CHEMBL175348 — — 1 9.40
CHEMBL366611 — — 1 9.40
CHEMBL176459 — — 1 9.40
CHEMBL433793 — — 1 9.40
CHEMBL174214 — — 1 9.40
CHEMBL262402 — — 1 9.40
CHEMBL177071 — — 1 9.30
CHEMBL367416 — — 1 9.30
CHEMBL367897 — — 1 9.30
CHEMBL173583 — — 1 9.30
CHEMBL368000 — — 1 9.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL369235 — IC50 = 0.2 nM 9.70
CHEMBL174927 — IC50 = 0.2 nM 9.70
CHEMBL173400 — IC50 = 0.2 nM 9.70
CHEMBL366770 — IC50 = 0.2 nM 9.70
CHEMBL171958 — IC50 = 0.2 nM 9.70
CHEMBL172916 — IC50 = 0.3 nM 9.52
CHEMBL367987 — IC50 = 0.3 nM 9.52
CHEMBL172894 — IC50 = 0.3 nM 9.52
CHEMBL435472 — IC50 = 0.3 nM 9.52
CHEMBL177127 — IC50 = 0.3 nM 9.52
CHEMBL369059 — IC50 = 0.3 nM 9.52
CHEMBL279992 — IC50 = 0.3 nM 9.52
CHEMBL366868 — IC50 = 0.3 nM 9.52
CHEMBL174004 — IC50 = 0.3 nM 9.52
CHEMBL368329 — IC50 = 0.3 nM 9.52
CHEMBL427493 — IC50 = 0.3 nM 9.52
CHEMBL366873 — IC50 = 0.4 nM 9.40
CHEMBL174214 — IC50 = 0.4 nM 9.40
CHEMBL433793 — IC50 = 0.4 nM 9.40
CHEMBL176459 — IC50 = 0.4 nM 9.40
CHEMBL369812 — IC50 = 0.4 nM 9.40
CHEMBL366611 — IC50 = 0.4 nM 9.40
CHEMBL262402 — IC50 = 0.4 nM 9.40
CHEMBL175348 — IC50 = 0.4 nM 9.40
CHEMBL176669 — IC50 = 0.4 nM 9.40
CHEMBL177071 — IC50 = 0.5 nM 9.30
CHEMBL173583 — IC50 = 0.5 nM 9.30
CHEMBL368000 — IC50 = 0.5 nM 9.30
CHEMBL175079 — IC50 = 0.5 nM 9.30
CHEMBL367416 — IC50 = 0.5 nM 9.30
CHEMBL367897 — IC50 = 0.5 nM 9.30
CHEMBL173479 — IC50 = 0.5 nM 9.30
CHEMBL369478 — IC50 = 0.5 nM 9.30
CHEMBL265723 — IC50 = 0.5 nM 9.30
CHEMBL366610 — IC50 = 0.5 nM 9.30
CHEMBL174996 — IC50 = 0.5 nM 9.30
CHEMBL369398 — IC50 = 0.5 nM 9.30
CHEMBL173091 — IC50 = 0.5 nM 9.30
CHEMBL369593 — IC50 = 0.5 nM 9.30
CHEMBL175341 — IC50 = 0.5 nM 9.30
CHEMBL176528 — IC50 = 0.5 nM 9.30
CHEMBL173254 — IC50 = 0.6 nM 9.22
CHEMBL369659 — IC50 = 0.6 nM 9.22
CHEMBL369494 — IC50 = 0.6 nM 9.22
CHEMBL367560 — IC50 = 0.6 nM 9.22
CHEMBL408800 — IC50 = 0.6 nM 9.22
CHEMBL172296 — IC50 = 0.6 nM 9.22
CHEMBL176426 — IC50 = 0.6 nM 9.22
CHEMBL368467 — IC50 = 0.6 nM 9.22
CHEMBL176933 — IC50 = 0.6 nM 9.22