Assay Detail
Functional
CHEMBL659102
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Compound was evaluated for the binding affinity for Caenorhabditis elegans avermectin using Caenorhabditis elegans membrane homogenates using [3H]IVM as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Caenorhabditis elegans |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Affinity probes for the avermectin binding proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.50 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405056 | — | — | 1 | 10.00 |
| CHEMBL6067487 | IVERMECTIN | 4.0 | 1 | 10.00 |
| CHEMBL428094 | — | — | 1 | 9.70 |
| CHEMBL263352 | — | — | 1 | 9.66 |
| CHEMBL412340 | — | — | 1 | 9.48 |
| CHEMBL429886 | — | — | 1 | 9.35 |
| CHEMBL128009 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405056 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL6067487 | IVERMECTIN | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL428094 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL263352 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL412340 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL429886 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL128009 | — | IC50 | = | 5.0 | nM | 8.30 |