Assay Detail
Functional
CHEMBL659188
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Compound was evaluated for anti-HIV activity against thymidine kinase deficient CEM cell line infected with HIV-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-HIV pronucleotides: decomposition pathways and correlation with biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.80 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311110 | — | — | 1 | 5.39 |
| CHEMBL9681 | — | — | 1 | 4.20 |
| CHEMBL9280 | — | — | 1 | - |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL9560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311110 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL9681 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL9280 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL9560 | — | EC50 | > | 10000.0 | nM | - |