Assay Detail
Functional
CHEMBL659189
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Compound was evaluated for antiviral activity against HIV-1 (IIIB) infected CEM cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphoramidate derivatives of 2,3-didehydro-2,3-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.30 |
| CHEMBL77652 | — | — | 1 | 8.22 |
| CHEMBL310839 | — | — | 1 | 8.10 |
| CHEMBL290427 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL77652 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL310839 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL290427 | — | EC50 | = | 20000.0 | nM | 4.70 |