Assay Detail
Functional
CHEMBL659193
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Compound was evaluated for the inhibition of HIV replication using HIV-2 infected CEM-TK- cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.97 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18099 | — | — | 1 | 7.22 |
| CHEMBL107184 | — | — | 1 | 7.12 |
| CHEMBL2311110 | — | — | 1 | 4.92 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.60 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18099 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL107184 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2311110 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL991 | STAVUDINE | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 100000.0 | nM | - |