Assay Detail
Functional
CHEMBL659229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for anti HIV activity in CEM-SS cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.81 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.42 |
| CHEMBL431573 | — | — | 1 | 7.20 |
| CHEMBL305179 | — | — | 1 | 7.20 |
| CHEMBL313761 | — | — | 1 | 6.90 |
| CHEMBL313674 | — | — | 1 | 6.89 |
| CHEMBL303397 | — | — | 1 | 6.67 |
| CHEMBL269559 | — | — | 1 | 6.58 |
| CHEMBL304144 | — | — | 1 | 6.42 |
| CHEMBL405649 | — | — | 1 | 6.31 |
| CHEMBL327259 | — | — | 1 | 6.23 |
| CHEMBL315916 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL431573 | — | EC50 | = | 63.5 | nM | 7.20 |
| CHEMBL305179 | — | EC50 | = | 63.5 | nM | 7.20 |
| CHEMBL313761 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL313674 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL303397 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL269559 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL304144 | — | EC50 | = | 376.0 | nM | 6.42 |
| CHEMBL405649 | — | EC50 | = | 494.0 | nM | 6.31 |
| CHEMBL327259 | — | EC50 | = | 584.0 | nM | 6.23 |
| CHEMBL315916 | — | EC50 | = | 763.0 | nM | 6.12 |