Assay Detail
Functional
CHEMBL659232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for inhibition against HIV-1 from CEM-SS cell lines.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.96 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336441 | — | — | 1 | 10.57 |
| CHEMBL137838 | — | — | 1 | 10.16 |
| CHEMBL141223 | — | — | 1 | 9.94 |
| CHEMBL138969 | — | — | 1 | 9.82 |
| CHEMBL329653 | — | — | 1 | 9.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336441 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL137838 | — | EC50 | = | 0.069 | nM | 10.16 |
| CHEMBL141223 | — | EC50 | = | 0.115 | nM | 9.94 |
| CHEMBL138969 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL329653 | — | EC50 | = | 0.47 | nM | 9.33 |