Assay Detail
Binding
CHEMBL659267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the inhibition human of Butyrylcholinesterase I
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.64 |
| CHEMBL12781 | — | — | 1 | 5.89 |
| CHEMBL12858 | — | — | 1 | 5.62 |
| CHEMBL12472 | — | — | 1 | 5.57 |
| CHEMBL268499 | — | — | 1 | 5.54 |
| CHEMBL12937 | — | — | 1 | 5.51 |
| CHEMBL13166 | — | — | 1 | 5.44 |
| CHEMBL275537 | — | — | 1 | 5.39 |
| CHEMBL13308 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL12781 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL12858 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL12472 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL268499 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL12937 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL13166 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL275537 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL13308 | — | IC50 | = | 4300.0 | nM | 5.37 |