Assay Detail
Functional
CHEMBL659285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration for cytopathicity of HIV-1 in CEM-SS cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.96 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294840 | — | — | 1 | 7.89 |
| CHEMBL63515 | — | — | 1 | 6.57 |
| CHEMBL418686 | — | — | 1 | 5.96 |
| CHEMBL65776 | — | — | 1 | 5.22 |
| CHEMBL63872 | — | — | 1 | 5.07 |
| CHEMBL58542 | — | — | 1 | 5.04 |
| CHEMBL65753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294840 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL63515 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL418686 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL65776 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL63872 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL58542 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL65753 | — | EC50 | = | 180000.0 | nM | - |