Assay Detail
Functional
CHEMBL659287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency to inhibit HIV-1 induced cytopathic effects in human T-lymphoblastic cells(CEM-SS) and essentially halted HIV-1 replication.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.32 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 7.00 |
| CHEMBL7121 | (+)-CALANOLIDE B | — | 1 | 6.40 |
| CHEMBL93010 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL7121 | (+)-CALANOLIDE B | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL93010 | — | EC50 | = | 2700.0 | nM | 5.57 |