Assay Detail
Binding
CHEMBL659315
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Inhibition of Caspase-1 enzyme
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.37 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323322 | — | — | 1 | 7.82 |
| CHEMBL322631 | — | — | 1 | 7.48 |
| CHEMBL3142757 | — | — | 1 | 7.06 |
| CHEMBL100559 | — | — | 1 | 6.90 |
| CHEMBL317246 | — | — | 1 | 6.60 |
| CHEMBL101182 | — | — | 1 | 6.48 |
| CHEMBL323570 | — | — | 1 | 6.47 |
| CHEMBL101145 | — | — | 1 | 6.42 |
| CHEMBL101622 | — | — | 1 | 6.10 |
| CHEMBL328155 | — | — | 1 | 5.72 |
| CHEMBL100591 | — | — | 1 | 5.66 |
| CHEMBL100643 | — | — | 1 | 5.59 |
| CHEMBL327298 | — | — | 1 | 5.53 |
| CHEMBL101545 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323322 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL322631 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3142757 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL100559 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL317246 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL101182 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL323570 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL101145 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL101622 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL328155 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL100591 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL100643 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL327298 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL101545 | — | IC50 | = | 4860.0 | nM | 5.31 |