Assay Detail
Functional
CHEMBL659425
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In vitro inhibitory activity against replication of HIV type-1 virus in CEM cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.04 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11116 | — | — | 1 | 9.10 |
| CHEMBL273368 | — | — | 1 | 8.17 |
| CHEMBL262714 | — | — | 1 | 7.92 |
| CHEMBL274186 | — | — | 1 | 7.80 |
| CHEMBL276656 | — | — | 1 | 7.50 |
| CHEMBL11143 | — | — | 1 | 7.31 |
| CHEMBL275237 | — | — | 1 | 7.23 |
| CHEMBL267092 | — | — | 1 | 7.08 |
| CHEMBL266398 | — | — | 1 | 6.97 |
| CHEMBL406991 | — | — | 1 | 6.49 |
| CHEMBL273827 | — | — | 1 | 6.32 |
| CHEMBL274569 | — | — | 1 | 6.19 |
| CHEMBL276833 | — | — | 1 | 5.30 |
| CHEMBL275592 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11116 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL273368 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL262714 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL274186 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL276656 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL11143 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL275237 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL267092 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL266398 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL406991 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL273827 | — | IC50 | = | 474.0 | nM | 6.32 |
| CHEMBL274569 | — | IC50 | = | 646.0 | nM | 6.19 |
| CHEMBL276833 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL275592 | — | IC50 | = | 5780.0 | nM | 5.24 |