Assay Detail
Functional
CHEMBL659459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Viral cytopathicity against HIV -I (HTLV-IIIb) strain determined in CEM cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.69 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138187 | — | — | 1 | 5.52 |
| CHEMBL3138268 | — | — | 1 | 4.62 |
| CHEMBL3137943 | — | — | 1 | 4.55 |
| CHEMBL3138267 | — | — | 1 | 4.08 |
| CHEMBL141281 | — | — | 1 | - |
| CHEMBL113197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138187 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3138268 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3137943 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3138267 | — | IC50 | = | 83300.0 | nM | 4.08 |
| CHEMBL141281 | — | IC50 | > | 110000.0 | nM | - |
| CHEMBL113197 | — | IC50 | > | 200000.0 | nM | - |