Assay Detail
Functional
CHEMBL659460
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Visual cytotoxicity scored on CEM cells at time of HCMV plaque enumeration
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.27 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143101 | — | — | 1 | 6.40 |
| CHEMBL3143102 | — | — | 1 | 5.70 |
| CHEMBL2112687 | — | — | 1 | 4.48 |
| CHEMBL473686 | — | — | 1 | 4.48 |
| CHEMBL2112691 | — | — | 1 | - |
| CHEMBL2111874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143101 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3143102 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2112687 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL473686 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2112691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2111874 | — | IC50 | > | 100000.0 | nM | - |