Assay Detail
Functional
CHEMBL659476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of [14C]-DDATHF influx in CEM/MTX cells of human leukemic lymphoblasts
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.64 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 6.36 |
| CHEMBL1679 | LEUCOVORIN | 4.0 | 1 | 6.13 |
| CHEMBL1622 | FOLIC ACID | 4.0 | 1 | 5.05 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL1679 | LEUCOVORIN | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL1622 | FOLIC ACID | Ki | = | 8950.0 | nM | 5.05 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 9740.0 | nM | 5.01 |