Assay Detail
Functional
CHEMBL659511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of the test compound required to inhibit the auto oxidative lipid peroxidations in canine brain homogenates by 50% was determined
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.94 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 5.82 |
| CHEMBL58192 | — | — | 1 | 5.19 |
| CHEMBL61492 | — | — | 1 | 5.16 |
| CHEMBL61436 | — | — | 1 | 4.89 |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 4.82 |
| CHEMBL444835 | — | — | 1 | 4.82 |
| CHEMBL61252 | — | — | 1 | 4.72 |
| CHEMBL58697 | — | — | 1 | 4.70 |
| CHEMBL61738 | — | — | 1 | 4.70 |
| CHEMBL58645 | — | — | 1 | 4.55 |
| CHEMBL302631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47 | ALPHA-TOCOPHEROL | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL58192 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL61492 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL61436 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL444835 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL61252 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL58697 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL61738 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL58645 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL302631 | — | IC50 | = | 390000.0 | nM | - |