Assay Detail
Binding
CHEMBL659587
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Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.69 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 8.14 |
| CHEMBL9387 | L-365260 | — | 1 | 7.82 |
| CHEMBL338525 | — | — | 1 | 7.82 |
| CHEMBL338300 | — | — | 1 | 7.73 |
| CHEMBL337934 | — | — | 1 | 7.70 |
| CHEMBL406359 | — | — | 1 | 7.49 |
| CHEMBL337933 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062154 | CI-988 | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL9387 | L-365260 | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL338525 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL338300 | — | Ki | = | 18.6 | nM | 7.73 |
| CHEMBL337934 | — | Ki | = | 19.9 | nM | 7.70 |
| CHEMBL406359 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL337933 | — | Ki | = | 74.9 | nM | 7.13 |