Assay Detail
Binding
CHEMBL659608
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In vitro inhibitory activity against coagulation factor X.
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 8.09 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367953 | — | — | 1 | 9.70 |
| CHEMBL175130 | — | — | 1 | 9.52 |
| CHEMBL369681 | — | — | 1 | 9.15 |
| CHEMBL435741 | — | — | 1 | 9.10 |
| CHEMBL174499 | — | — | 1 | 9.10 |
| CHEMBL176243 | — | — | 1 | 9.05 |
| CHEMBL176671 | — | — | 1 | 9.05 |
| CHEMBL174558 | — | — | 1 | 9.00 |
| CHEMBL174791 | — | — | 1 | 8.96 |
| CHEMBL369023 | — | — | 1 | 8.89 |
| CHEMBL368095 | — | — | 1 | 8.89 |
| CHEMBL177444 | — | — | 1 | 8.85 |
| CHEMBL172360 | — | — | 1 | 8.82 |
| CHEMBL366358 | — | — | 1 | 8.82 |
| CHEMBL355807 | — | — | 1 | 8.70 |
| CHEMBL177109 | — | — | 1 | 8.70 |
| CHEMBL426416 | — | — | 1 | 8.64 |
| CHEMBL368494 | — | — | 1 | 8.46 |
| CHEMBL369015 | — | — | 1 | 8.44 |
| CHEMBL175033 | — | — | 1 | 8.42 |
| CHEMBL369086 | — | — | 1 | 8.40 |
| CHEMBL176210 | — | — | 1 | 8.30 |
| CHEMBL173832 | — | — | 1 | 8.24 |
| CHEMBL174731 | — | — | 1 | 8.20 |
| CHEMBL175014 | — | — | 1 | 8.17 |
| CHEMBL172256 | — | — | 1 | 8.16 |
| CHEMBL425858 | — | — | 1 | 8.15 |
| CHEMBL174968 | — | — | 1 | 8.00 |
| CHEMBL176757 | — | — | 1 | 8.00 |
| CHEMBL368126 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367953 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL175130 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL369681 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL435741 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL174499 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL176243 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL176671 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL174558 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL174791 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL369023 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL368095 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL177444 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL172360 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL366358 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL177109 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL355807 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL426416 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL368494 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL369015 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL175033 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL369086 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL176210 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL173832 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL174731 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL175014 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL172256 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL425858 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL174968 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL176757 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL368126 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL369177 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL368614 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL176268 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL367340 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL425859 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL175031 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL175122 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL368323 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL174870 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL368914 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL176736 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL176451 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL366894 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL176856 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL174740 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL368744 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL175142 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL366647 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL175125 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL174111 | — | IC50 | = | 230.0 | nM | 6.64 |