Assay Detail
Binding
CHEMBL659667
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Evaluated for its activity against carbonic anhydrase (CA) in anesthetized rabbits
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.62 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65455 | — | — | 1 | 7.85 |
| CHEMBL423848 | — | — | 1 | 7.75 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.70 |
| CHEMBL294799 | — | — | 1 | 7.70 |
| CHEMBL65604 | — | — | 1 | 7.70 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.70 |
| CHEMBL64055 | — | — | 1 | 7.70 |
| CHEMBL293684 | — | — | 1 | 7.70 |
| CHEMBL303108 | — | — | 1 | 7.43 |
| CHEMBL62782 | — | — | 1 | 7.30 |
| CHEMBL430596 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65455 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL423848 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL19 | METHAZOLAMIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL294799 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL65604 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL64055 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL293684 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL303108 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL62782 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL430596 | — | IC50 | = | 50.0 | nM | 7.30 |