Assay Detail
Binding
CHEMBL659702
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Inhibitory activity against Caspase-8
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent and selective nonpeptide inhibitors of caspases 3 and 7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.31 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60306 | — | — | 1 | 4.51 |
| CHEMBL62993 | — | — | 1 | 4.31 |
| CHEMBL1907830 | — | — | 1 | 4.10 |
| CHEMBL293622 | — | — | 1 | - |
| CHEMBL62187 | — | — | 1 | - |
| CHEMBL439753 | — | — | 1 | - |
| CHEMBL60190 | — | — | 1 | - |
| CHEMBL305545 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60306 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL62993 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL1907830 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL293622 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL62187 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL439753 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL60190 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL305545 | — | Ki | > | 50000.0 | nM | - |