Assay Detail
Binding
CHEMBL659710
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Inhibition of Caspase-8 enzyme
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.62 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322631 | — | — | 1 | 8.12 |
| CHEMBL100643 | — | — | 1 | 7.92 |
| CHEMBL3142757 | — | — | 1 | 7.77 |
| CHEMBL101545 | — | — | 1 | 7.51 |
| CHEMBL101145 | — | — | 1 | 7.32 |
| CHEMBL328155 | — | — | 1 | 6.70 |
| CHEMBL323322 | — | — | 1 | 6.35 |
| CHEMBL100559 | — | — | 1 | 6.21 |
| CHEMBL101182 | — | — | 1 | 6.17 |
| CHEMBL327298 | — | — | 1 | 6.13 |
| CHEMBL101622 | — | — | 1 | 6.00 |
| CHEMBL323570 | — | — | 1 | 5.92 |
| CHEMBL100591 | — | — | 1 | 5.85 |
| CHEMBL317246 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322631 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL100643 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3142757 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL101545 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL101145 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL328155 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL323322 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL100559 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL101182 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL327298 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL101622 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL323570 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL100591 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL317246 | — | IC50 | = | 19590.0 | nM | 4.71 |