Assay Detail
Binding
CHEMBL659799
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Binding affinity against Chymotrypsin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.42 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285285 | — | — | 1 | 10.96 |
| CHEMBL418050 | — | — | 1 | 10.68 |
| CHEMBL291026 | — | — | 1 | 9.94 |
| CHEMBL290577 | — | — | 1 | 9.82 |
| CHEMBL2448441 | — | — | 1 | 9.07 |
| CHEMBL3349045 | — | — | 1 | 8.92 |
| CHEMBL287918 | — | — | 1 | 8.92 |
| CHEMBL288176 | — | — | 1 | 8.84 |
| CHEMBL291261 | — | — | 1 | 8.54 |
| CHEMBL36744 | — | — | 1 | 8.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285285 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL418050 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL291026 | — | Ki | = | 0.115 | nM | 9.94 |
| CHEMBL290577 | — | Ki | = | 0.152 | nM | 9.82 |
| CHEMBL2448441 | — | Ki | = | 0.848 | nM | 9.07 |
| CHEMBL3349045 | — | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL287918 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL288176 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL291261 | — | Ki | = | 2.89 | nM | 8.54 |
| CHEMBL36744 | — | Ki | = | 2.96 | nM | 8.53 |