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Assay Detail

CHEMBL659869

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro concentration required for 50% inhibition of swelling of cat cerebrocortical slices
41
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Felis catus
Confidence 1 — Organism
Curated By Expert

Target

Felis catus (CHEMBL612670)
Type ORGANISM
Organism Felis catus

Publication

Agents for the treatment of brain edema. 2. [(2,3,9,9a-Tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)oxy]+ ++alkanoi c acids and some of their analogues.
Cragoe EJ, Woltersdorf OW, Gould NP, Pietruszkiewicz AM, Ziegler C, Sakurai Y, Stokker GE, Anderson PS, Bourke RS, Kimelberg HK.
J Med Chem (1986) 29 : 825 -841
PubMed 3701792 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 8.28 10.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL165590 3 10.70
CHEMBL169992 1 10.40
CHEMBL168310 3 10.00
CHEMBL167245 1 10.00
CHEMBL167244 2 9.30
CHEMBL170217 1 9.15
CHEMBL168244 1 9.00
CHEMBL169884 1 9.00
CHEMBL352136 2 8.52
CHEMBL169218 1 8.52
CHEMBL355545 1 8.00
CHEMBL168295 3 8.00
CHEMBL354146 1 7.70
CHEMBL168997 1 7.30
CHEMBL168298 1 7.00
CHEMBL166394 1 7.00
CHEMBL412812 1 7.00
CHEMBL170216 1 6.00
CHEMBL169220 1 -
CHEMBL170002 1 -
CHEMBL165696 1 -
CHEMBL169809 1 -
CHEMBL170796 1 -
CHEMBL165641 1 -
CHEMBL168331 1 -
CHEMBL168463 1 -
CHEMBL167046 1 -
CHEMBL353436 1 -
CHEMBL166498 1 -
CHEMBL169223 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL165590 IC50 = 0.02 nM 10.70
CHEMBL169992 IC50 = 0.04 nM 10.40
CHEMBL165590 IC50 = 0.04 nM 10.40
CHEMBL168310 IC50 = 0.1 nM 10.00
CHEMBL167245 IC50 = 0.1 nM 10.00
CHEMBL168310 IC50 = 0.2 nM 9.70
CHEMBL167244 IC50 = 0.5 nM 9.30
CHEMBL170217 IC50 = 0.7 nM 9.15
CHEMBL168244 IC50 = 1.0 nM 9.00
CHEMBL169884 IC50 = 1.0 nM 9.00
CHEMBL167244 IC50 = 1.0 nM 9.00
CHEMBL169218 IC50 = 3.0 nM 8.52
CHEMBL352136 IC50 = 3.0 nM 8.52
CHEMBL352136 IC50 = 6.0 nM 8.22
CHEMBL168295 IC50 = 10.0 nM 8.00
CHEMBL355545 IC50 = 10.0 nM 8.00
CHEMBL354146 IC50 = 20.0 nM 7.70
CHEMBL168295 IC50 = 30.0 nM 7.52
CHEMBL168997 IC50 = 50.0 nM 7.30
CHEMBL168298 IC50 = 100.0 nM 7.00
CHEMBL166394 IC50 = 100.0 nM 7.00
CHEMBL412812 IC50 = 100.0 nM 7.00
CHEMBL170216 IC50 = 1000.0 nM 6.00
CHEMBL165590 IC50 = 10000.0 nM 5.00
CHEMBL168295 IC50 = 30000.0 nM 4.52
CHEMBL169220 IC50 > 100.0 nM -
CHEMBL353252 IC50 = 0.004 nM -
CHEMBL170002 IC50 = 0.002 nM -
CHEMBL166926 IC50 > 100.0 nM -
CHEMBL166619 IC50 > 100.0 nM -
CHEMBL169223 IC50 > 10.0 nM -
CHEMBL166498 IC50 > 100.0 nM -
CHEMBL353436 IC50 > 1000.0 nM -
CHEMBL167046 IC50 > 10.0 nM -
CHEMBL168463 IC50 > 10000.0 nM -
CHEMBL168331 IC50 > 10.0 nM -
CHEMBL168310 IC50 >> 10000.0 nM -
CHEMBL165641 IC50 > 10.0 nM -
CHEMBL170796 IC50 > 10000.0 nM -
CHEMBL169809 IC50 > 10.0 nM -
CHEMBL165696 IC50 > 1000.0 nM -