Assay Detail
Binding
CHEMBL659916
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Binding affinity for Cholecystokinin type A receptor using [125I]BH-CCK-8 in rat pancreatic tissue
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.62 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161142 | — | — | 1 | 10.52 |
| CHEMBL423907 | — | — | 1 | 10.52 |
| CHEMBL137280 | — | — | 1 | 10.15 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 10.05 |
| CHEMBL345049 | — | — | 1 | 9.70 |
| CHEMBL1791002 | — | — | 1 | 9.62 |
| CHEMBL1791005 | — | — | 1 | 9.28 |
| CHEMBL136096 | — | — | 1 | 9.01 |
| CHEMBL341762 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161142 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL423907 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL137280 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL1121 | SINCALIDE | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL345049 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1791002 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1791005 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL136096 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL341762 | — | Ki | = | 19.0 | nM | 7.72 |