Assay Detail
Binding
CHEMBL659926
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In vitro Inhibitory activity against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMC
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.64 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114410 | — | — | 1 | 9.15 |
| CHEMBL323638 | — | — | 1 | 8.52 |
| CHEMBL113706 | — | — | 1 | 8.34 |
| CHEMBL116041 | — | — | 1 | 8.10 |
| CHEMBL326093 | — | — | 1 | 8.00 |
| CHEMBL117928 | — | — | 1 | 7.24 |
| CHEMBL326342 | — | — | 1 | 7.16 |
| CHEMBL323637 | — | — | 1 | 6.68 |
| CHEMBL115822 | — | — | 1 | 5.60 |
| CHEMBL323704 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114410 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL323638 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL113706 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL116041 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL326093 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL117928 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL326342 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL323637 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL115822 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL323704 | — | IC50 | > | 2500.0 | nM | - |