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Assay Detail

CHEMBL660133

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Binding
Inhibition of Bovine Cathepsin D
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cathepsin D (CHEMBL4106)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.
Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA.
J Med Chem (1992) 35 : 2562 -2572
PubMed 1635057 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.40 7.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL314066 1 7.07
CHEMBL313063 1 6.89
CHEMBL420417 1 6.12
CHEMBL87389 1 6.08
CHEMBL34894 1 5.90
CHEMBL316208 1 5.66
CHEMBL405227 1 5.43
CHEMBL431217 1 5.19
CHEMBL88091 1 5.05
CHEMBL86374 1 4.84
CHEMBL316218 1 4.60
CHEMBL60610 1 4.52
CHEMBL315380 1 4.29
CHEMBL430634 1 4.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL314066 IC50 = 85.5 nM 7.07
CHEMBL313063 IC50 = 130.0 nM 6.89
CHEMBL420417 IC50 = 763.0 nM 6.12
CHEMBL87389 IC50 = 834.0 nM 6.08
CHEMBL34894 IC50 = 1250.0 nM 5.90
CHEMBL316208 IC50 = 2170.0 nM 5.66
CHEMBL405227 IC50 = 3700.0 nM 5.43
CHEMBL431217 IC50 = 6400.0 nM 5.19
CHEMBL88091 IC50 = 8900.0 nM 5.05
CHEMBL86374 IC50 = 14500.0 nM 4.84
CHEMBL316218 IC50 = 25000.0 nM 4.60
CHEMBL60610 IC50 = 30000.0 nM 4.52
CHEMBL315380 IC50 = 51800.0 nM 4.29
CHEMBL430634 IC50 = 95000.0 nM 4.02