Assay Detail
Binding
CHEMBL660145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration on Bovine Cathepsin D
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.02 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60550 | TERLAKIREN | 2.0 | 1 | 7.62 |
| CHEMBL299252 | — | — | 1 | 6.29 |
| CHEMBL293196 | — | — | 1 | 5.89 |
| CHEMBL292677 | — | — | 1 | 4.29 |
| CHEMBL293328 | — | — | 1 | - |
| CHEMBL431751 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60550 | TERLAKIREN | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL299252 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL293196 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL292677 | — | IC50 | = | 51800.0 | nM | 4.29 |
| CHEMBL293328 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL431751 | — | IC50 | > | 1000.0 | nM | - |