Assay Detail
Binding
CHEMBL660349
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
INCORPORATION OF CONFORMATIONALLY CONSTRAINED PHENYLALANINE DERIVATIVES TIC, SIC, HIC AND NIC INTO A CHOLECYSTOKININ-B/GASTRIN RECEPTOR ANTAGONIST
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.32 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26167 | — | — | 1 | 8.30 |
| CHEMBL24313 | — | — | 1 | 8.28 |
| CHEMBL24276 | — | — | 1 | 6.75 |
| CHEMBL26390 | — | — | 1 | 6.65 |
| CHEMBL285305 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26167 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL24313 | — | IC50 | = | 5.248 | nM | 8.28 |
| CHEMBL24276 | — | IC50 | = | 177.83 | nM | 6.75 |
| CHEMBL26390 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL285305 | — | IC50 | = | 234.42 | nM | 6.63 |