Assay Detail
Binding
CHEMBL660355
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In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.91 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415936 | — | — | 1 | 9.13 |
| CHEMBL14557 | — | — | 1 | 8.96 |
| CHEMBL299540 | — | — | 1 | 8.92 |
| CHEMBL298521 | — | — | 1 | 8.91 |
| CHEMBL296167 | — | — | 1 | 8.80 |
| CHEMBL299387 | — | — | 1 | 8.41 |
| CHEMBL53237 | — | — | 1 | 8.39 |
| CHEMBL298551 | — | — | 1 | 8.35 |
| CHEMBL24313 | — | — | 1 | 8.28 |
| CHEMBL297480 | — | — | 1 | 8.27 |
| CHEMBL301777 | — | — | 1 | 8.12 |
| CHEMBL301810 | — | — | 1 | 7.88 |
| CHEMBL280248 | — | — | 1 | 7.87 |
| CHEMBL298861 | — | — | 1 | 7.82 |
| CHEMBL300456 | — | — | 1 | 7.80 |
| CHEMBL53129 | — | — | 1 | 6.47 |
| CHEMBL301095 | — | — | 1 | 6.27 |
| CHEMBL301740 | — | — | 1 | 6.05 |
| CHEMBL52740 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415936 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL14557 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL299540 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL298521 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL296167 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL299387 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL53237 | — | Ki | = | 4.074 | nM | 8.39 |
| CHEMBL298551 | — | Ki | = | 4.467 | nM | 8.35 |
| CHEMBL24313 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL297480 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL301777 | — | Ki | = | 7.586 | nM | 8.12 |
| CHEMBL301810 | — | Ki | = | 13.18 | nM | 7.88 |
| CHEMBL280248 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL298861 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL300456 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL53129 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL301095 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL301740 | — | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL52740 | — | Ki | = | 2884.03 | nM | 5.54 |